Prostaglandin-D synthase

prostaglandin-D synthase
Identifiers
EC number 5.3.99.2
CAS number 65802-85-9
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a prostaglandin-D synthase (EC 5.3.99.2) is an enzyme that catalyzes the chemical reaction

(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13- dienoate \rightleftharpoons (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate

Thus, the two substrates of this enzyme are (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13- and dienoate, whereas its product is (5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate.

This enzyme belongs to the family of isomerases, specifically a class of other intramolecular oxidoreductases. The systematic name of this enzyme class is (5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Delta-isomerase. Other names in common use include prostaglandin-H2 Delta-isomerase, prostaglandin-R-prostaglandin D isomerase, and PGH-PGD isomerase. This enzyme participates in arachidonic acid metabolism.

Structural studies

As of late 2001, 7 structures have been solved for this class of enzymes, with PDB accession codes 1IYH, 1IYI, 1PD2, 1V40, 2CZT, 2CZU, and 2E4J.

References